ACS Bio & Med Chem Au
OUR SCIENCE
Publications.
Research on infection networks, molecular interactions and antimicrobial discovery.
67 publications
European Journal of Medicinal Chemistry,310:118784
Targeting Staphylococcus aureus with Potent De Novo-Designed Proline-Core Short Antimicrobial Lipopeptides
Veterinary Research,56:173
Exploring the therapeutic potential of recombinant bovine β-defensins for antimicrobial and anti-inflammatory functions in sepsis management
Journal of Cheminformatics,17:144
Evaluating Ligand Docking Methods for Drugging Protein–Protein Interfaces: Insights from Alphafold2 and Molecular Dynamics Refinement
Biofilm, 10:100301
Time-resolved dual transcriptomics of Pseudomonas aeruginosa biofilm formation in cystic fibrosis
Molecular Systems Biology, 1-22
Mining the heparinome for cryptic antimicrobial peptides that selectively kill gram-negative bacteria
Computational and Structural Biotechnology Journal, 23:972-981
The limits of prediction: Why intrinsically disordered regions challenge our understanding of antimicrobial peptides
International journal of molecular sciences, 25:9773
From In Vitro Promise to In Vivo Reality: An Instructive Account of Infection Model Evaluation of Antimicrobial Peptides
Critical Reviews in Microbiology, 1-36
The battle within: how Pseudomonas aeruginosa uses host-pathogen interactions to infect the human lung
Pharmaceutics, 15(6), 1777
The C-Terminus of Panusin, a Lobster β-Defensin, Is Crucial for Optimal Antimicrobial Activity and Serum Stability
Bioinformatics, 39:btac847
The PRALINE database: Protein and Rna humAn singLe nucleotIde variaNts in condEnsates
Computational and Structural Biotechnology Journal, 20:6534-6542
HPIPred: Host-Pathogen Interactome Prediction with phenotypic scring
Pharmaceutics, 14:2169
Antimicrobial Peptides can Generate Tolerance by Lag and Interfere with Antimicrobial Therapy
International Journal of Molecular Sciences, 23:11489
Analysis of Host–Bacteria Protein Interactions Reveals Conserved Domains and Motifs That Mediate Fundamental Infection Pathways
IUBMB Life, 75:411-426
A high-throughput approach to predict A-to-I effects on RNA structure indicates a change of double-stranded content in non-coding RNAs
Biomedicines, 10:2110
Examining Topoisomers of a Snake-Venom-Derived Peptide for Improved Antimicrobial and Antitumoral Properties
ACS Infect. Dis., 8:1207-1217
Essential Role of Enzymatic Activity in the Leishmanicidal Mechanism of the Eosinophil Cationic Protein (RNase 3)
Biomedicines, 10:386
In Vivo Evaluation of ECP Peptide Analogues for the Treatment of Acinetobacter baumannii Infection
J. Mol. Biol, 434:167159
The interplay between disordered regions in RNAs and proteins modulates interactions within stress granules and processing bodies
J. Med. Chem, 64:11472-11482
Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability
J. Mol. Biol. 434:167159
The Interplay Between Disordered Regions in RNAs and Proteins Modulates Interactions Within Stress Granules and Processing Bodies
Microorganisms, 9:354
Time-Resolved Transcriptional Profiling of Epithelial Cells Infected by Intracellular Acinetobacter baumannii
Nucleic Acids Res, 49:D687–D693
DualSeqDB: the host–pathogen dual RNA sequencing database for infection processes
Cell. Mol. Life Sci, In Press
Human RNase3 immune modulation by catalytic-dependent and independent modes in a macrophage-cell line infection model
Nucleic Acids Research, 48:9491–9504
RNA-binding and prion domains: the Yin and Yang of phase separation
PLoS Comput Biol 16(12): e1008395
Bacteria use structural imperfect mimicry to hijack the host interactome
Nucleic Acids Research, 48:D511-D516
BacFITBase: a database to assess the relevance of bacterial genes during host infection
Microorganisms, 7:292
A coordinated response at the transcriptome and interactome level is required to ensure uropathogenic Escherichia coli survival during bacteremia
International journal of molecular sciences, 20:4558
Insight into the antifungal mechanism of action of human RNase N-terminus derived peptides.
Molecular Systems Biology, 15:e8075
The fitness cost and benefit of phase separated protein deposits
European Journal of Medicinal Chemistry, 152:590-599
Positional Scanning Library applied to the human eosinophil cationic protein/RNase3 N-terminus reveals novel and potent anti-biofilm peptides
Science Signalling, 11: eaat6409
Cells alter their tRNA abundance to selectively regulate protein expression during stress conditions
Journal of The Royal Society Interface, 14:20170423
Structural similarities in the CPC clip motif explain peptide-binding promiscuity between glycosaminoglycans and lipopolysaccharides
Nature Communications, 8: 14092
Centrality in the host-pathogen interactome is associated with pathogen fitness during infection
FEBS Journal, 283 (22), 4176-4191
Structural basis for endotoxin neutralization by the Eosinophil Cationic Protein
Antimicrobial agents and Chemotherapy, 60(10):6313-6325
A novel RNase 3/ECP peptide for Pseudomonas aeruginosa biofilm eradication. Combining antimicrobial, lipopolysaccharide binding and cell agglutinating activities.
International Journal of Molecular Sciences, 17(4):552
Insights into the antimicrobial mechanism of action of human RNase 6: structural determinants for bacterial cell agglutination and membrane permeation
Cellular and Molecular Life Sciences 72(24):4795-4805
Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases?
pages 101-118; Springer, ISBN: 978-1-4939-2239-0
Prediction of bioactive peptides using artificial neural networks. Methods in molecular biology: Artificial Neural Networks, edited by Hugh Cartwright
FEBS Journal 280(22):5841-5852
Towards the rational design of antimicrobial proteins: single point mutations can switch on bactericidal and agglutinating activities on the RNase A superfamily lineage
Biochemical Journal 456(1):99-108
Ribonucleases as a host-defense family: Evidence of evolutionary conserved antimicrobial activity at the N-terminus.
Antimicrobial Agents and Chemotherapy 57(8):3797-3805
Two human host defense ribonucleases against mycobacteria: the eosinophil cationic protein (ECP/RNase 3) and RNase 7.
PLoS Pathogens 8(11):e1003005
Exploring new biological functions of amyloids: bacteria cell agglutination mediated by host protein aggregation
PLoS ONE 7(8):e42692
The "CPC clip motif": a conserved structural signature for heparin-binding proteins
Biological Chemistry 393(8):801-815
Structural determinants of the eosinophil cationic protein antimicrobial activity
Current drug targets 13(9):1148-1157
Discovering new in silico tools for antimicrobial peptide prediction
Journal of Innate Immunity 4(4):327-336
Lipopolysaccharide neutralization by antimicrobial peptides: a gambit in the innate host defense strategy
Antimicrobial Agents and Chemotherapy 56(5):2378-85
Antimicrobial action and cell agglutination by the eosinophil cationic protein are modulated by the cell wall lipopolysaccharide structure
Bioinformatics 28(1):130-131
AMPA: an automated web server for prediction of protein antimicrobial regions
Angewandte Chemie International Edition 50(45):10686-91068
The generation of antimicrobial peptide activity: a trade-off between charge and aggregation?
Journal of Medicinal Chemistry 54(14):5237-5244
Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization
PLoS ONE 6(2):e16968
Connecting peptide physicochemical and antimicrobial properties by a rational prediction model
Biochimie 93(2):331-338
Mapping the eosinophil cationic protein antimicrobial activity by chemical and enzymatic cleavage
Biomacromolecules 11(8):1983-1990
Eosinophil cationic protein aggregation: identification of an N-terminus amyloid prone region
Journal of Molecular Recognition 24(1):90-100
Eosinophil cationic protein (ECP) can bind heparin and other glycosaminoglycans through its RNase active site
FEBS Journal 277(7):1713-1725
Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall
Biochemical Journal 421(3):425-434
Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment
BBA-Biomembranes 1788(5):1116-1125
Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7
Current pharmaceutical biotechnology 9(3):141-152
The antipathogen activities of eosinophil cationic protein
Biochemistry 47(11):3544-3555
Eosinophil cationic protein high-affinity binding to bacteria-wall lipopolysaccharides and peptidoglycans
Biochemistry 46(3):720-733